| Rank | Name | Team | G | Batters Faced | IP | TBA | TOP |
|---|---|---|---|---|---|---|---|
| 1 | Johan Santana | MIN | 34 | 923 | 233.2 | 360 | 0.393 |
| 2 | Chris Carpenter | STL | 32 | 896 | 221.2 | 350 | 0.396 |
| 3 | Chien-Ming Wang | NYY | 34 | 900 | 218.0 | 367 | 0.409 |
| 4 | Brandon Webb | ARI | 33 | 950 | 235.0 | 388 | 0.413 |
| 5 | CC Sabathia | CLE | 28 | 802 | 192.2 | 328 | 0.413 |
| 6 | Roy Halladay | TOR | 32 | 876 | 220.0 | 364 | 0.417 |
| 7 | Mike Mussina | NYY | 32 | 804 | 197.1 | 336 | 0.418 |
| 8 | John Lackey | LAA | 33 | 922 | 217.2 | 386 | 0.423 |
| 9 | Érik Bédard | BAL | 33 | 844 | 196.1 | 357 | 0.426 |
| 10 | Derek Lowe | LAD | 35 | 913 | 218.0 | 386 | 0.426 |
| 11 | Roy Oswalt | HOU | 33 | 896 | 220.2 | 380 | 0.430 |
| 12 | John Smoltz | ATL | 35 | 960 | 232.0 | 417 | 0.436 |
| 13 | Carlos Zambrano | CHC | 33 | 917 | 214.0 | 396 | 0.437 |
| 14 | Kelvim Escobar | LAA | 30 | 789 | 189.1 | 343 | 0.438 |
| 15 | Bronson Arroyo | CIN | 35 | 992 | 240.2 | 431 | 0.438 |
| 16 | Josh Johnson | FLA | 31 | 659 | 157.0 | 285 | 0.440 |
| 17 | Jason Schmidt | SFG | 32 | 894 | 213.1 | 391 | 0.441 |
| 18 | Kenny Rogers | DET | 34 | 849 | 204.0 | 375 | 0.442 |
| 19 | Ervin Santana | LAA | 33 | 846 | 204.0 | 374 | 0.444 |
| 20 | Clay Hensley | SDP | 37 | 787 | 187.0 | 349 | 0.449 |
| 21 | Jason Jennings | COL | 32 | 902 | 212.0 | 406 | 0.454 |
| 22 | Jake Westbrook | CLE | 32 | 904 | 211.1 | 408 | 0.454 |
| 23 | Matt Cain | SFG | 32 | 818 | 190.2 | 368 | 0.456 |
| 24 | Justin Verlander | DET | 30 | 776 | 186.0 | 353 | 0.457 |
| 25 | Pedro Martinez | NYM | 23 | 550 | 132.2 | 249 | 0.458 |
| 26 | Mark Hendrickson | TOT | 31 | 719 | 164.2 | 327 | 0.458 |
| 27 | Dontrelle Willis | FLA | 34 | 975 | 223.1 | 442 | 0.459 |
| 28 | Adam Loewen | BAL | 22 | 504 | 112.1 | 231 | 0.459 |
| 29 | José Contreras | CHW | 30 | 833 | 196.0 | 382 | 0.460 |
| 30 | Jeremy Bonderman | DET | 34 | 903 | 214.0 | 414 | 0.460 |
| 31 | Aaron Cook | COL | 32 | 915 | 212.2 | 418 | 0.461 |
| 32 | Tom Glavine | NYM | 32 | 842 | 198.0 | 383 | 0.461 |
| 33 | Kevin Millwood | TEX | 34 | 907 | 215.0 | 415 | 0.462 |
| 34 | Javier Vázquez | CHW | 33 | 872 | 202.2 | 402 | 0.462 |
| 35 | Scott Kazmir | TBD | 24 | 610 | 144.2 | 282 | 0.462 |
| 36 | Félix Hernández | SEA | 31 | 816 | 191.0 | 379 | 0.466 |
| 37 | Dan Haren | OAK | 34 | 930 | 223.0 | 433 | 0.467 |
| 38 | Dave Bush | MIL | 34 | 869 | 210.0 | 402 | 0.467 |
| 39 | Greg Maddux | TOT | 34 | 862 | 210.0 | 398 | 0.468 |
| 40 | Daniel Cabrera | BAL | 26 | 662 | 148.0 | 309 | 0.470 |
| 41 | Jaret Wright | NYY | 30 | 625 | 140.1 | 293 | 0.471 |
| 42 | Randy Johnson | NYY | 33 | 860 | 205.0 | 404 | 0.473 |
| 43 | Scott Olsen | FLA | 31 | 761 | 180.2 | 357 | 0.473 |
| 44 | Nate Robertson | DET | 32 | 881 | 208.2 | 416 | 0.474 |
| 45 | Chris Capuano | MIL | 34 | 936 | 221.1 | 440 | 0.475 |
| 46 | Jeff Francis | COL | 32 | 843 | 199.0 | 397 | 0.475 |
| 47 | Aaron Harang | CIN | 36 | 993 | 234.1 | 462 | 0.475 |
| 48 | Barry Zito | OAK | 34 | 945 | 221.0 | 448 | 0.478 |
| 49 | Curt Schilling | BOS | 31 | 834 | 204.0 | 397 | 0.479 |
| 50 | Vicente Padilla | TEX | 33 | 872 | 200.0 | 416 | 0.480 |
| 51 | Jake Peavy | SDP | 32 | 846 | 202.1 | 405 | 0.482 |
| 52 | Jarrod Washburn | SEA | 31 | 809 | 187.0 | 389 | 0.483 |
| 53 | Jon Garland | CHW | 33 | 900 | 211.1 | 432 | 0.483 |
| 54 | A.J. Burnett | TOR | 21 | 577 | 135.2 | 277 | 0.483 |
| 55 | Brett Myers | PHI | 31 | 833 | 198.0 | 400 | 0.484 |
| 56 | Esteban Loaiza | OAK | 26 | 679 | 154.2 | 327 | 0.485 |
| 57 | Doug Davis | MIL | 34 | 904 | 203.1 | 431 | 0.485 |
| 58 | Cole Hamels | PHI | 23 | 558 | 132.1 | 268 | 0.486 |
| 59 | Zach Duke | PIT | 34 | 935 | 215.1 | 448 | 0.486 |
| 60 | Woody Williams | SDP | 25 | 624 | 145.1 | 301 | 0.488 |
| 61 | Brad Penny | LAD | 34 | 813 | 189.0 | 393 | 0.488 |
| 62 | Gil Meche | SEA | 32 | 811 | 186.2 | 395 | 0.489 |
| 63 | Cliff Lee | CLE | 33 | 882 | 200.2 | 430 | 0.489 |
| 64 | Kyle Lohse | TOT | 34 | 566 | 126.2 | 273 | 0.489 |
| 65 | Miguel Batista | ARI | 34 | 910 | 206.1 | 440 | 0.490 |
| 66 | Jamey Wright | SFG | 34 | 676 | 156.0 | 331 | 0.493 |
| 67 | Joe Blanton | OAK | 32 | 856 | 194.1 | 421 | 0.494 |
| 68 | Chris Young | SDP | 31 | 735 | 179.1 | 360 | 0.495 |
| 69 | Matt Morris | SFG | 33 | 903 | 207.2 | 443 | 0.496 |
| 70 | Noah Lowry | SFG | 27 | 689 | 159.1 | 339 | 0.500 |
| 71 | Jon Lieber | PHI | 27 | 714 | 168.0 | 354 | 0.500 |
| 72 | Ricky Nolasco | FLA | 35 | 613 | 140.0 | 303 | 0.501 |
| 73 | Andy Pettitte | HOU | 36 | 929 | 214.1 | 459 | 0.502 |
| 74 | Jeff Suppan | STL | 32 | 837 | 190.0 | 415 | 0.502 |
| 75 | Tim Wakefield | BOS | 23 | 610 | 140.0 | 306 | 0.502 |
| 76 | Brad Radke | MIN | 28 | 689 | 162.1 | 345 | 0.504 |
| 77 | Ted Lilly | TOR | 32 | 797 | 181.2 | 400 | 0.504 |
| 78 | Chuck James | ATL | 25 | 504 | 119.0 | 250 | 0.505 |
| 79 | Tim Hudson | ATL | 35 | 959 | 218.1 | 481 | 0.506 |
| 80 | Jamie Moyer | TOT | 33 | 894 | 211.1 | 452 | 0.509 |
| 81 | Liván Hernández | TOT | 34 | 959 | 216.0 | 480 | 0.509 |
| 82 | James Shields | TBD | 21 | 540 | 124.2 | 274 | 0.511 |
| 83 | Paul Maholm | PIT | 30 | 788 | 176.0 | 400 | 0.512 |
| 84 | Eric Milton | CIN | 26 | 662 | 152.2 | 337 | 0.514 |
| 85 | Tony Armas | WSN | 30 | 693 | 154.0 | 350 | 0.514 |
| 86 | Casey Fossum | TBD | 25 | 594 | 130.0 | 305 | 0.515 |
| 87 | Freddy García | CHW | 33 | 917 | 216.1 | 473 | 0.516 |
| 88 | Chan Ho Park | SDP | 24 | 606 | 136.2 | 308 | 0.517 |
| 89 | Josh Beckett | BOS | 33 | 869 | 204.2 | 449 | 0.518 |
| 90 | Orlando Hernández | TOT | 29 | 699 | 162.1 | 359 | 0.519 |
| 91 | Mark Redman | KCR | 29 | 740 | 167.0 | 381 | 0.519 |
| 92 | Paul Byrd | CLE | 31 | 805 | 179.0 | 419 | 0.521 |
| 93 | Sean Marshall | CHC | 24 | 563 | 125.2 | 290 | 0.522 |
| 94 | John Koronka | TEX | 23 | 554 | 125.0 | 289 | 0.523 |
| 95 | Claudio Vargas | ARI | 31 | 747 | 167.2 | 387 | 0.524 |
| 96 | Cory Lidle | TOT | 31 | 745 | 170.2 | 388 | 0.524 |
| 97 | Mark Buehrle | CHW | 32 | 876 | 204.0 | 458 | 0.526 |
| 98 | Steve Trachsel | NYM | 30 | 736 | 164.2 | 386 | 0.527 |
| 99 | Ian Snell | PIT | 32 | 813 | 186.0 | 421 | 0.528 |
| 100 | Kris Benson | BAL | 30 | 781 | 183.0 | 408 | 0.528 |
| 101 | Wandy Rodríguez | HOU | 30 | 611 | 135.2 | 321 | 0.531 |
| 102 | Rodrigo López | BAL | 36 | 847 | 189.0 | 449 | 0.533 |
| 103 | Ramón Ortiz | WSN | 33 | 871 | 190.2 | 461 | 0.535 |
| 104 | Byung-Hyun Kim | COL | 27 | 689 | 155.0 | 367 | 0.539 |
| 105 | Kirk Saarloos | OAK | 35 | 548 | 121.1 | 298 | 0.546 |
| 106 | Josh Fogg | COL | 31 | 765 | 172.0 | 414 | 0.546 |
| 107 | Joel Piñeiro | SEA | 40 | 753 | 165.2 | 412 | 0.548 |
| 108 | Óliver Pérez | TOT | 22 | 529 | 112.2 | 288 | 0.550 |
| 109 | Odalis Pérez | TOT | 32 | 573 | 126.1 | 314 | 0.552 |
| 110 | Jeff Weaver | TOT | 31 | 770 | 172.0 | 425 | 0.557 |
| 111 | Víctor Santos | PIT | 25 | 522 | 115.1 | 288 | 0.557 |
| 112 | Brian Moehler | FLA | 29 | 556 | 122.0 | 310 | 0.565 |
| 113 | Carlos Silva | MIN | 36 | 811 | 180.1 | 455 | 0.565 |
| 114 | Jason Marquis | STL | 33 | 870 | 194.1 | 485 | 0.565 |
| 115 | Jason Johnson | TOT | 24 | 527 | 115.0 | 298 | 0.568 |
| 116 | Runelvys Hernández | KCR | 21 | 508 | 109.2 | 287 | 0.568 |
| 117 | Jae Weong Seo | TOT | 36 | 707 | 157.0 | 400 | 0.571 |
| 118 | Ryan Madson | PHI | 50 | 620 | 134.1 | 351 | 0.574 |
| 119 | Jorge Sosa | TOT | 45 | 524 | 118.0 | 298 | 0.576 |
| 120 | Shawn Chacón | TOT | 26 | 516 | 109.0 | 310 | 0.609 |
Stats sourced from Baseball-Reference